Traveling westbound on Interstate 70 - Take Utah State Highway 24 west towards Hanksville exit 149. Stay on Highway 24 for 95 miles to reach the park Visitor Center.
Traveling on Interstate 15 - Take US Highway 50 east at Scipio exit 188 towards Salina for 30 miles. At the junction with Utah State Highway 89/259, turn right south and travel 8 miles. Turn left east onto Utah State Highway 24 towards Sigurd. Continue on Highway 24 for 82 miles to reach the park Visitor Center.
If you are OK with being way off the beaten track, you can reach the skinny south end of the park via the remote Burr Trail Road, which runs from Boulder in the west through some awe inspiring stretches of Grand Staircase-Escalante National Monument, and then runs southeast of the park to Bullfrog Marina in the desolate reaches of the Glen Canyon National Recreation Area. Be prepared that the road is not paved within the park, and the unavoidable gravelly ride down the Burr Trail Switchbacks is extremely steep, and not likely passable in rain or when wet.